The USB Connection is turned Off by default. Primarily, the best way to print is by using an SD card. This prevents issues such as USB latency and other issues that stop the flow of data from the computer to the printer.
It is sometimes helpful to be able to directly control the printer via the computer though. This version of Slic3r has the capability, but it need to be turn on first.
In the upper left hand corner of the program choose "File" and then choose "Preferences"
A dialog will pop up. Uncheck Disable USB / serial connection and then choose OK
Slic3r will notify you that the program needs to be restarted for this to take effect. Close the program and re-open it.
When it re-opens you will find that there is a tab labeled "Controller" Before Slic3r will be able to communicate we need to help it "find" your printer. Turn your printer on and make sure that the USB cable is connected to the Printer and Computer. Also make sure that there are no other programs open that will take over communication:
Click on the gear icon in line with "Printer" (on the right hand side of the screen). This will open the printer setting. With your printer powered on and USB cable connected, choose the correct COM port for your printer, ensure that the Speed is set to 250000 and then click "Test"
You should see a Success dialog. The computer and printer are now able to communicate with each other. Close the dialog, and then click the blue save icon in the upper left hand corner of the Printer Settings Dialog. Choose OK in the Save As dialog that appears.
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