Slic3r has three main settings divisions: Print Settings, Filament, and Printer
Print Settings are as the name suggests, specific to things such as layer height, infill, speeds, support, etc.
Filament Settings are settings that effect temperature & cooling settings
Printer Settings are settings specific to your printer such as bed shape and size, Heated Bed (yes/no) Start and End GCODE, etc.
For Printer Settings, be sure to set the active setting to your machine type. ie Rostock Max v3, Orion Delta, etc.
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